Prometic Bioseparations
"Your Trusted Partner in Protein Purification and Bioseparations"
Our Mission
At Prometic Bioseparations, our mission is to provide high-performance and innovative purification solutions tailored to the evolving needs of the biopharmaceutical and plasma-derived therapeutics industries. We are dedicated to enhancing lives by supporting the manufacture of safe, effective, and high-quality biologics.
Our Vision
is to set the global standard in bioseparations by providing innovative, reliable, and customized solutions for every purification challenge. We go beyond simply supplying products we strive to be a trusted strategic partner, supporting you at every stage of your bioprocessing journey to ensure efficiency, quality, and success.
We bring over three decades of experience in chromatography and large-scale purification, making us a trusted partner in bioprocessing.
Our track record includes 18 FDA-approved chromatography adsorbents currently used in the manufacturing processes of 12 approved therapeutic products.
Why Choose Us?
Purification of Native and Recombinant Proteins
In the field of bioprocessing, chromatography resins play a critical role in the isolation and purification of two primary categories of proteins: Native proteins, which are directly extracted from biological sources such as human plasma, animal tissues, or plant materials. Recombinant proteins, which are produced by genetically modified organisms (e.g., bacteria, yeast, or mammalian cells) using recombinant DNA technology. Each type of protein comes with its own purification challenges. Native proteins often require gentle handling to preserve their biological function, while recombinant proteins are typically accompanied by host cell impurities. Chromatography enables the precise and selective purification of these proteins, making the process both efficient and scalable.
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Types of Chromatography Resins: Standard vs. Custom
To address diverse purification needs across various applications, chromatography resins are available in two main formats:
Standard (Off-the-Shelf) Resins :
These resins are pre-designed with broad specificity and are ideal for common targets and well-established workflows. They offer a quick, cost-effective solution during early development stages or for routine manufacturing.
Custom (Bespoke) Resins :
These resins are tailor-made to suit specific process requirements, such as isolating rare proteins, improving selectivity, or enhancing yields in complex matrices. Developed in collaboration with clients, custom resins provide flexibility and performance in specialised applications
Elimination of Contaminants
Protein purification goes far beyond simply isolating the desired target molecule it plays a critical role in ensuring product safety, stability, and efficacy by removing unwanted impurities and process-related contaminants. These contaminants may include host cell proteins (HCPs) originating from the production cell line, DNA fragments, endotoxins, viruses, aggregates, and other process residuals such as chromatography ligands or leachables from purification resins. If not effectively eliminated, these impurities can trigger immune responses, compromise product potency, or shorten shelf life.
Modern purification workflows employ a combination of chromatography techniques (affinity, ion exchange, size exclusion), filtration, and polishing steps to achieve high purity levels that meet stringent regulatory requirements. Continuous monitoring through sensitive analytical methods such as ELISA, LC-MS, and qPCR ensures that contaminant levels remain within safe limits. This rigorous approach guarantees that the final therapeutic product is both clinically effective and compliant with global quality standards, protecting patient safety while optimizing manufacturing efficiency.
Prometic Bioseparations plays a key role in the purification and manufacture of plasma-derived therapeutics, providing essential technologies that ensure product safety and quality.
Trusted Solutions for Plasma-Derived Therapeutics
Prometic Bioseparations is a well-established name in the field of bioseparations, offering critical support to the biopharmaceutical industry, especially in the purification and manufacturing of plasma-derived medicines. With over 30 years of experience, Prometic has honed its expertise in chromatography and bioseparation technologies to address the unique challenges involved in processing human plasma—a complex and sensitive biological material.
The company provides a wide range of both standard and customised chromatography resins that are specifically designed to ensure the efficient isolation and purification of plasma proteins. These solutions help in removing impurities and contaminants, thereby maintaining the highest standards of safety, purity, and efficacy required by regulators worldwide.
By partnering with pharmaceutical manufacturers, Prometic Bioseparations plays a vital role in enabling the reliable production of plasma-derived therapies that are essential for treating conditions such as immune deficiencies, bleeding disorders, and other serious health issues. Their commitment to innovation and quality makes them a trusted collaborator in delivering life-saving medicines to patients across the globe.
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